Although the importance of nuclear architecture has been debated for decades, the paradigm has been changing rapidly, owing to the development of new technologies. In the nervous system, dynamic rearrangement of the nuclear architecture has been observed in each cell type, especially in neurons, allowing for their specialized functions, including learning and memory formation. These subnuclear components operate together as epigenetic regulators of neural development and function and are collectively called the nuclear architecture. The nucleus is a well-organized subcellular organelle that includes chromatin, the nuclear lamina, and nuclear bodies. These programs are controlled by the epigenetic regulatory layers in the nucleus. Neurons and glial cells in the nervous system exhibit different gene expression programs for neural development and function.
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